Knee pain is a common complaint, can be seen in all ages and is most often associated with aging and injury. Knee pain is the second most common cause of chronic pain which can lead to a poor quality of life and disability. The causes are as numerous as the treatments. It is important that all health care professional recognize and then execute a successful, individually formulated treatment plan. In this two-hour lecture, we will explore the causes of knee pain, diagnosis and treatment options as well as new therapies and research.